Yes, the Rite of Marriage may be celebrated within a Liturgy of the Word.
The Rite of Marriage provides for both a Nuptial Mass as well as a wedding ceremony outside of Mass. Generally, a marriage between a Catholic person and a non-Catholic person should be celebrated outside of Mass.
However, The Eucharist is the primary sacrament. All other sacraments, including Marriage, find their source and meaning in the Eucharist. In this primary sacrament, it is the total self-donation of Jesus that nourishes and gives life to the Church.
By virtue of their Baptism, the couple already shares in Christ’s marriage covenant with the Church. It is fitting, therefore, that the marriage celebration of a Catholic man and a Catholic woman be performed within a Nuptial Mass.